Welcome to the Bosco Lab at Dartmouth.

Chromosomes.  Chromatin.  Epigenetics.  Learning.  Memory.  Aging.

Explore our lab website and learn more about these active research projects and the people who work on them.

 

2017 Nobel Prize in Medicine goes to three Drosophila biologists!  Jeff Hall and Michael Rosbash of Brandeis University and Michael Young of Rockefeller University share this year's Nobel prize for their discovery of molecular mechanisms of circadian clocks.  They all used fruit flies as their model system that led them to understand the molecules that control biological clocks of all animals (not just fruit flies). A good day for fruit flies and basic discovery science! Click here to read more about it.

 

 

Mechanical force exerted by condensin II pulls nuclear envelope into the interior of the nucleus and forms intra-nuclear vesicles.

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Polytene chromosomes help us localize Mrg15 protein and condensin II subunit Cap-H2.

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The mushroom body of the adult Drosophila brain is shown above and is labeled with green fluorescent protein.  Flies learn about the presence of predators and then talk about it with their siblings! These social interactions trigger dramatic physiological and behavioral changes that persist for days. Are these behaviors inherited through multiple generations? If so, what are the molecular mechanisms of such memory inheritance?

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